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The physiological rationale is that the two peptides target different receptor systems in the anterior pituitary that work together in the natural regulation of GH secretion

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Key Differences Between Sermorelin and Ipamorelin The core difference between sermorelin and ipamorelin comes down to receptor pathway: sermorelin activates the GHRH receptor, while ipamorelin activates the ghrelin receptor and that single distinction accounts for most of the other differences researchers compare between them