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222 In a randomized controlled trial in elderly patients with mild cognitive impairment living in the United Kingdom, supplementing with 800 mcg folic acid, 500 mcg B 12 , and 20 mg B 6 daily for two years reduced atrophy of gray matter (brain tissue most vulnerable to Alzheimer pathology) up to seven-fold in those with baseline homocysteine levels higher than 11 μmol/L

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doi: 10.1016/j.ijpharm.2022.121792 [DOI] [PubMed] [Google Scholar] 128.Cortese F, Cecere A, Maria Cortese A, Andriani A, Truncellito L, Valente F, et al