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Altered redox status may contribute to aberrant folliculogenesis and poor reproductive outcomes in women with polycystic ovary syndrome | Journal of Assisted Reproduction and Genetics | Springer Nature Link
From a clinical and applied standpoint, this supports the notion of moving toward cycle-aware, but not rigidly “cycle-synced,” strategies: for most healthy, well-nourished women, modest phase-dependent adaptations—such as ensuring adequate energy and micronutrient intake in the mid-luteal phase, or considering the timing of high-intensity exercise relative to phases associated with lower subjective well-being—are likely to be sufficient, whereas in conditions such as PCOS, obesity, diabetes or functional hypothalamic amenorrhea, a more deliberate alignment of nutrition and training with endocrine and inflammatory profiles may help stabilize glycemic control, ovulatory function, and symptom burden [95,172]
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doi: 10.1038/ncomms4128 Summary Keywords NADPH, macrophages, LPS (lipopolysaccharide), myeloid cells, immunometabolism, dendritic cells, cofactors, cofactor coordination Citation Ting KKY, Jongstra-Bilen J and Cybulsky MI (2023) The multi-faceted role of NADPH in regulating inflammation in activated myeloid cells
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